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Sensors

Detection of Human Growth Hormone (hGH) via Cyclodextrin-Promoted Fluorescence Modulation

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Pages 1871-1880 | Received 24 Aug 2020, Accepted 21 Sep 2020, Published online: 07 Oct 2020
 

Abstract

The ability to detect human growth hormone (hGH) via sensitive, selective, and easy-to-use methods is a high priority research area from a variety of public health, law enforcement, and scientific objectives. Reported herein is the use of cyclodextrin-promoted fluorescence modulation of a high-quantum yield BODIPY fluorophore in the presence of low concentrations of hGH, leading to a system that can detect hGH in concentrations as low as 0.279 µM and with a 96% accuracy in distinguishing different hGH concentrations.

Additional information

Funding

Funding in support of this research was provided by the Rhode Island Foundation through their Clean Competition Fund.

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