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Fluorescence

Hemicyanine-Based Fluorescent Probe for Distinguishing Cysteine in Living HeLa Cells

ORCID Icon, , , , &
Pages 2666-2675 | Received 27 Oct 2020, Accepted 22 Jan 2021, Published online: 09 Feb 2021
 

Abstract

Cysteine (Cys) is a crucial biomarker and plays various significant roles in many physiological and pathological processes. Here is reported a fluorescent probe Mito-cys by incorporating o-chlorobenzoic acid ester onto a hemicyanine platform. The probe exhibited excellent specificity and rapid response for cysteine. The developed method quantitatively monitored cysteine from 5 μM to 30 μM with a detection limit of 135 nM. The probe was also employed to image trace endogenous cysteine in living HeLa cells.

Additional information

Funding

This work was supported by the Key Scientific Research Program of the Higher Education Institution of Henan Province (18A150003).

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