Electrodeposition of Cerium Oxide Nanoparticles on the Graphenized Carbon Ceramic Electrode (GCCE) for the Sensitive Determination of Isoprenaline in Human Serum by Differential Pulse Voltammetry (DPV)

Abstract

Cerium oxide nanoparticles (CeO₂) are widely used as the electrocatalyst in solar cells, fuel cells, water splitting, and electroanalytical experiments. Therefore, controlled electrodeposition of CeO₂ on the surface of electrodes may improve the performance of electrochemical devices. CeO₂ was electrochemically deposited on the surface of a graphenized carbon ceramic electrode (GCCE) for the determination of isoprenaline in biological samples. The pH, temperature, deposition time, and applied potential were optimized for the electrodeposition. According to differential pulse voltammetry, the linear range, detection limit, and sensitivity of the designed assay were from 5 to 310 nM, 3.03 nM and 25.21 × 10⁻⁵µA µM⁻¹cm⁻², respectively. Easy preparation, low cost, and high production repeatability of the developed CeO₂/GCCE suggest further applications. The prepared modified electrode was successfully utilized for the determination of isoprenaline in human serum with satisfactory results.

Keywords:

• Cerium oxide nanoparticles
• differential pulse voltammetry (DPV)
• graphenized carbon ceramic electrode (GCCE)
• isoprenaline

Acknowledgments

This project was performed according to ethical standards (IR.TBZMED.VCR.REC.1397.062).

Additional information

Funding

The authors gratefully acknowledge Azarbaijan Shahid Madani University for financial support.