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Abstract
The interfacial and redox behaviour of clonazepam was studied by adsorptive stripping voltammetry at a hanging mercury drop electrode (HMDE). The results obtained by linear scan mode indicate that the electron transfer is preceded by adsorption, a Frumkin-type adsorption process being established. Determination of clonazepam can be performed at nanomolar levels using differential pulse mode. The best conditions were obtained in 0.025 M carbonate buffer of pH 10.0, with an accumulation potential of -0.30 V. The influence of urine components on the voltammetric response was also studied. Albumin and uric acid were found to interfere to a significant degree, making a preliminary separation of the drug by extraction a necessity. The proposed method is appropiate for determation of clonazepam in urine UP to 550 ng mHof urine, with a 10 ng ml-betection limit at 60 s of accumulation t i eand a relative standard deviation lower than 2.9%