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Abstract
A simple, precise and rapid high performance thin layer chromatographic method is developed using chloroform: methanol (9:1) as mobile phase for simultaneous determination of Theophylline and Etofylline in pharmaceutical dosages. Paracetamol was used as an internal standard. The method is linear in the concentration range of 20 – 80 ng for Theophylline and 60–240 ng for Etofylline.
The Rf values are 0.58, 0.48, 0.41 for Theophylline, Etofylline and Paracetamol respectively.
Minimum detection limit obtained was 10 ng for both Theophylline and Etofylline.
Results obtained are statistically comparable.
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