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Pharmaceutical Analysis

Cathodic Stripping Voltammetric Determination of Cefaclor in Pharmaceutical Formulations

Pages 97-109 | Published online: 18 Feb 2008
 

Abstract

A sensitive method is described for the determination of cefaclor by cathodic stripping voltammetry at the hanging mercury drop electrode. cefaclor is accumulated at the electrode surface as a mercury salt, which is reduced at −0.67 V. The optimum accumulation potential and accumulation time were +0.15 V and up to 180 s, respectively. Linear calibration graphs were obtained between 3.9 μg.L−1 to 39 μg.L−1 and the limit of determination was evaluated to be 1.9 μg.L−1. The method was applied successfully to the determination of cefaclor in pharmaceutical formulations.

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