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Abstract
We measured the uptake of ozone by the surgically isolated upper airways in 11 anesthetized, paralyzed, mechanically ventilated dogs. The gas was administered either by nose or mouth, each exposure lasting 20 to 30 minutes. The relative uptake of O3 was found to be inversely related to concentration and flow rate, and was higher nasally than orally. Changes in nasal flow resistance, induced by aerosols of histamine and phenylephrine (Neo-Synephrïne) hydrochloride, had little effect on the process. The removal of O3 from inspired air by the lower airways and parenchyma was measured in five additional dogs that were mechanically ventilated through a tracheal cannula. The concentration ranged from 20 to 85 pphm, the tidal volume was constant, and the pump frequently was either 20 or 30 cycles per minute. Under these circumstances, the rate of uptake varied between 80% and 87%.