Short-Term Toxicity of Mevinphos in Man

Abstract

This is a report of two cases of acute, moderate toxicity to mevinphos. Symptomatology was similar to that previously reported for exposure to parathion or sarin.

Excretion pattern for the alkyl phosphate ester dimethylphosphate (DMP) shows rapid excretion that is almost complete 50 hours after exposure to mevinphos. Total excretion of DMP equivalent to 7.7 mg and 9.2 mg, respectively, of mevinphos was measured in two cases. Blood coagulation studies showed marked fibrinolysis in one case and marked hypercoagulability in the other, as demonstrated by the thrombin generation curve. Hematuria persisted in one patient for more than eight days.

Both patients responded well to treatment. There was a five- to ten-hour delay between exposure and the patient reporting to the hospital for treatment.