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Abstract
The effect of prolonged and repeated exposure of mice to low levels of ozone was studied during a 120-day period. During this time, severe alterations were observed in the synthesis of lung DNA (decreased), RNA (decreased), and protein (increased).
Parallel studies involving key enzymes (glutamic oxaloacetic transaminase, lactic dehydrogenase, and alkaline phosphatase) correlated with the aforementioned synthesis suggested that the effects of ozone, later demonstrable in the appearance of lung abnormalities, are first preceded by biochemical changes, all of which are related to cell injury.