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Abstract
Rabbit alveolar macrophages were exposed in vitro to 5μm Teflon particles coated with aluminium, beryllium, carbon, chromium, lead, manganese, silver, and uranium. Compared with silver-coated particles the number of phagocytized particles in 1.5 hours was higher for aluminium- and chromium-coated particles and similar for manganese- and uraniumcoated particles when serum was added. The difference was less pronounced when serum was not added.
Beryllium-coated particles were highly toxic for the macrophages (increased number of dead macrophages and different appearance in light microscope).