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Abstract
• Tracheobronchial clearance was measured in mine healthy, nonsmoking adults. Technetium Tc 99m albumin aerosol (mass median diameter, 3μ; geometric standard deviation, 1.3) was inhaled as a bolus under controlled conditions to achieve reproducible deposition in large airways. Each subject was studied in three separate three-hour experiments: twice under control conditions and once exposed to 5 ppm sulfur dioxide (pollutant exposure after aerosol inhalation). Lung retention of activity was measured using a gamma camera interfaced to a data storage and retrieval system.
The study showed that (1) Both deposition and clearance were highly reproducible in individuals in repeat control studies. (2) Acute exposure to 5 ppm sulfur dioxide had no significant effect (P>.05) on mucociliary clearance in resting healthy subjects, except perhaps for a small transient change (P=.05) after one hour. (3) Pulmonary function tests showed a decrease in maximal midexpiratory flow (P<.01), but no other significant changes.