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British Poultry Science Volume 53, 2012 - Issue 6
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Genetics

Molecular cloning, expression and regulation analysis of the interleukin-6 (IL-6) gene in goose adipocytes

F. Wang College of Animal Sciences, Zhejiang University, Hangzhou, PR China
,
Y. Tian Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
G. Li Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
X. Chen Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
H. Yuan Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
D. Wang Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
J. Li Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
J. Shen Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
Z. Tao Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences
,
Y. Fu College of Animal Sciences, Zhejiang University, Hangzhou, PR China
&
Dr L. Lu Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural SciencesCorrespondence[email protected]
 show all
Pages 741-746 | Accepted 04 Jun 2012, Published online: 11 Feb 2013
 
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Abstract

1. Interleukin-6 (IL-6) is a multifunctional cytokine involved in lipid metabolism in adipose tissue. The objective of the study was to identify and characterize the IL-6 gene in the goose.

2. A full-length coding sequence (CDS) of the goose (Anser anser) IL-6 gene was cloned that encoded a 234-amino acid peptide containing a 38-amino acid signal peptide, an IL-6/G-CSF/MGF family consensus pattern and four conserved α-helices. The mature goose IL-6 showed 74% and 39% identities to that of chicken and human, respectively.

3. Quantitative real-time PCR analysis showed that the goose IL-6 was predominantly expressed in liver and was up-regulated in adipocytes by lipopolysaccharide (LPS) and oleic acid.

Acknowledgments

This work was funded by International Cooperation Project, China (project no. 2008DFA31060) and Significant Project of Zhejiang Province, China (project no. 2007C12058).

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