Single-dose toxicokinetics of permethrin in broiler chickens

Abstract

1. Single-dose toxicokinetics of permethrin was investigated in broiler chickens.

2. A total of 20 male broiler chickens were assigned at random to two groups of 10 at 30 days of age. A single dose of 10 mg/kg body weight of permethrin was administered intravenously to the first group; in the second group, the same dose was administered into the crop.

3. Serum permethrin was measured using an electron capture detector and gas chromatography equipment. The derived serum permethrin concentration/time curve demonstrated that the distribution kinetics of permethrin was well described by a two-compartment open model.

4. For intravenous permethrin administration, the half-life at λ phase (t_1/2λ), mean residence time (MRT) and area under the concentration–time curve in 0→∞ (AUC_0→∞) values respectively were 4.73 ± 1.00 h, 5.06 ± 1.05 h and 16.45 ± 3.28 mg/h/l. In contrast, the C_max, t_max, t_1/2λ, MRT and AUC_0→∞ values respectively of the group given intra-crop permethrin were 0.60 ± 0.42 μg/ml, 0.55 ± 0.19 h, 5.54 ± 0.78 h, 7.06 ± 0.63 h and 1.95 ± 0.97 mg/h/l. The bioavailability of permethrin was 0.11.

5. For both administration routes, the residence time of permethrin in the body was short and the bioavailability of permethrin was low. These results are relevant for assessing the use and safety of permethrin.

ACKNOWLEDGEMENT

This study is the MSc thesis of Turgut Gögebakan.

Additional information

Funding

The research [project code: TSY-11-3820] was supported by the Research Fund of Erciyes University.