Effect of lipopolysaccharides from pathogenic bacteria on broiler chickens’ productivity: a meta-analysis

ABSTRACT

1. This meta-analysis investigated the impact of LPS and covariates (serotype, rearing period and administration route) on the productivity parameters of broiler chickens (average daily feed intake (ADFI), average daily gain (ADG) and feed conversion ratio (FCR)).

2. Thirty-two eligible studies were included. Hedges’ g effect size was determined using a random-effects model at 95% confidence interval.

3. Results showed that LPS significantly decreased average daily feed intake (ADFI; p < 0.0001) and average daily gain (ADG; p < 0.0001) and increased FCR (p < 0.0001). The serotypes Escherichia coli 055: B5 (EC055: B5) and Escherichia coli 0127: B8 (EC 0127: B8) significantly reduced ADFI and ADG, and the serotype EC 055: B5 significantly increased the FCR (p < 0.05).

4. The intraperitoneal administration of the LPS significantly reduced the productivity of broiler chickens (p < 0.05), but other administration routes did not show such effects. The reduction in ADFI and ADG was found in all rearing periods (p < 0.05), and the increase in FCR was observed in the starter (p = 0.0302) and grower periods (p = 0.0031).

5. Exposure to LPS significantly reduced the productivity of broiler chickens (p < 0.05). However, no relationship was observed between LPS dosage and productivity as indicated by the meta-regression study.

6. The findings indicated that LPS has detrimental effects on broiler chickens’ ADFI, ADG and FCR across various LPS serotypes and rearing periods. These detrimental impacts of LPS remain consistent regardless of the administered dosage.

KEYWORDS:

• LPS
• serotypes
• administration
• dosage
• performance

Acknowledgments

The authors would like to thank the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia for providing financial assistance for the research project through the Pendidikan Magister Menuju Doctor untuk Sarjana Unggul (PMDSU) scholarship with the contract number 089/E5/PG.02.00.PT/2022; 2013/UN1/DITLIT/Dit-Lit/PT.01.03/2022.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article.

Additional information

Funding

The work was supported by the Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi [089/E5/PG.02.00.PT/2022; 2013/UN1/DITLIT/Dit-Lit/P].