![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
The volatile anesthetic agent isoflurane was thought to provide neuroprotection against ischemic damage; however, this effect remains controversial. Using the middle cerebral artery occlusion model and intracerebral microdialysis, the authors monitored the variations of glutamate and taurine concentrations in the extra-cellular space in male rats anesthetized with pentobarbital or isoflurane. Brain injury and edema were evaluated 24 h after ischemia. Isoflurane prevented the ischemia-induced efflux of glutamate and reduced the release of taurine. No difference in the size of the brain lesions was observed with both anesthetics, and isoflurane induced the formation of a bigger brain edema and reduced taurine release. These results suggest that inhibiting glutamate release during ischemia may not be sufficient to improve brain outcome after transient ischemia.
| Abbreviations | ||
| MCAO | = | middle cerebral artery occlusion |
| ECA | = | external carotid artery |
| ICA | = | internal carotid artery |
| aCSF | = | artificial cerebrospinal fluid |
| AEC | = | 3-amino-9-ethylcarbazole |
| MAP-2 | = | microtubule associated protein 2 |
| GFAP | = | glial fibrillary acidic protein. |
| Abbreviations | ||
| MCAO | = | middle cerebral artery occlusion |
| ECA | = | external carotid artery |
| ICA | = | internal carotid artery |
| aCSF | = | artificial cerebrospinal fluid |
| AEC | = | 3-amino-9-ethylcarbazole |
| MAP-2 | = | microtubule associated protein 2 |
| GFAP | = | glial fibrillary acidic protein. |