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International Journal of Neuroscience Volume 115, 2005 - Issue 8
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ASSOCIATION ANALYSIS OF SEROTONIN TRANSPORTER PROMOTER GENE POLYMORPHISM WITH ADHD AND RELATED SYMPTOMATOLOGY

AI-LING ZHAO Departmemt of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, People's Republic of China
,
LIN-YAN SU Departmemt of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, People's Republic of China
,
YU-HU ZHANG Department of Neurology, Xiang Ya Hospital, Central South University, Changsha Hunan, People's Republic of China
,
BEI-SHA TANG Department of Neurology, Xiang Ya Hospital, Central South University, Changsha Hunan, People's Republic of China
,
XUE-RONG LUO Departmemt of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, People's Republic of China
,
CHUN-XIANG HUANG Departmemt of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, People's Republic of China
&
QIAO-RONG SU Departmemt of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, People's Republic of China
 show all
Pages 1183-1191 | Received 27 Sep 2004, Published online: 07 Jul 2009
 
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Abstract

Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop attention deficit hyperactivity disorder. Several investigations have reported associations between ADHD and serotonin transporter promoter polymorphisms, but the results have been inconsistent. The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele.

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