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International Journal of Neuroscience Volume 115, 2005 - Issue 10
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Original

EXPRESSION OF TIGHT AND GAP JUNCTIONAL PROTEINS IN THE PERINEURIAL WINDOW MODEL OF THE RAT SCIATIC NERVE

MITUHIKO OHTA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
SEIICHIRO OKAJIMA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
HISANORI HIRAKAWA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
DAISAKU TOKUNAGA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
HIROYOSHI FUJIWARA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
RYO ODA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
HIROAKI KOBASHI Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
,
MIYUKI HIRATA Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
&
TOSHIKAZU KUBO Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, KyotoJapan
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Pages 1469-1481 | Received 26 Feb 2005, Published online: 07 Jul 2009
 
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Abstract

Limited perineurial injury, known as a perineurial window, can lead to neuropathic pain. This article hypothesizes that the recovery of the perineurium is associated with the intercellular junctional proteins. It analyzes the expressions of occludin, ZO-1, and connexin 43 by immunoconfocal microscopy. Seven days after injury, immunoreactivities for occludin and ZO-1 were observed, although there was no connexin 43 detected. Then, 21 days after injury, immunoreactivity for connexin 43 were observed. These results indicate that recovery of the perineurium is associated with the intercellular junctional proteins and that the recovery of gap junctions is delayed compared with that of tight junctions.

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