Abstract
This study was to elucidate the role of genetic variation in androgen receptor (AR) gene, estrogen receptor α (ER α) and ER β gene on first-onset major depressive disorder (MDD) in female adolescents. Results showed that AR gene in MDD group have shorter microsatellites’ length, and ER β gene have shorter microsatellites’ length and higher rates of S alleles, SS, genotype, and lower rate of LL genotype than control group. The results suggest that shorter length of AR and ER β gene microsatellites might influence the onset of MDD in female adolescents, a further elucidation of the mechanisms is warranted.