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International Journal of Neuroscience Volume 117, 2007 - Issue 7
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STEREOTYPIC CIRCLING BEHAVIOR IN MICE WITH VESTIBULAR DYSFUNCTION: ASYMMETRICAL EFFECTS OF INTRASTRIATAL MICROINJECTION OF A DOPAMINE AGONIST

AKIO ISHIGURO Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan and Division of Reproductive Developmental and Aging Science, The University of Tokyo Graduate School of Medicine, Tokyo, Japan; Department of Developmental Disorders, National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan
,
MASUMI INAGAKI Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan and Division of Reproductive Developmental and Aging Science, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
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MAKIKO KAGA Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan and Division of Reproductive Developmental and Aging Science, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
Pages 1049-1064 | Received 19 May 2006, Published online: 07 Jul 2009
 
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Abstract

Bronx Waltzer (bv) mouse, which has been used as a model of hearing and vestibular dysfunction, shows remarkable repetitive circling behavior. This study investigated whether the behavior is caused by the asymmetry of striatal function by observing the behavior of the bv mice following microinjection of dopamine D1 agonist, A68930 into the striatum ipsilaterally and contralaterally to the preferred direction of rotation separately. High dose of the drug induced opposite effects on ipsilateral rotations by the side of injections with statistical significance (p = .0026). These results suggested that the stereotypic circling behavior involves striatum and is based on striatal asymmetry.

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