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International Journal of Neuroscience Volume 118, 2008 - Issue 1
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THE EFFECT OF PROGESTERONE ON TOTAL BRAIN TISSUE SIALIC ACID LEVELS IN EXPERIMENTAL EPILEPSY

SADRETTIN PENCE Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey
,
MEHMET BOSNAK Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey
,
NACIYE KURTUL Department of Chemistry, Faculty of Science Sutcu Imam University, Kahramanmaras, Turkey
,
METE GUROL UGUR Department of Obstetrics & Gynecology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey
,
IBRAHIM ERKUTLU Department of Neurosurgery, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey
,
CAHIT BAGCI Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey
&
UNER TAN Department of Physiology, Medical School Cukurova University, Adana, Turkey
 show all
Pages 105-118 | Received 23 Jun 2006, Published online: 24 Aug 2009
 
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Abstract

Epilepsy, the most common neurological disorder worldwide, changing cellular interactions and connectivity may have effects on sialic acid levels. A total of 80 mice were separated into 8 groups: the sham, control, pentylentetrazole (PTZ), PTZ plus progesterone, five dose progesterone, single dose progesterone, kindling, and kindling plus progesterone groups. Brains of each mice were extracted and were divided into five parts. The sialic acid levels were significantly different between the groups and also in the subgroups. The results suggested that progesterone may have an anti-seizure effect by decreasing sialic acid levels in mice. Further studies are needed to evaluate the role of progesterone on sialic acid levels and its role in the epilepsy pathogenesis.

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