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International Journal of Neuroscience Volume 118, 2008 - Issue 3
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Original

Effect of Growth Hormone on Cyclooxygenase-2 Expression in the Hippocampus of Rats Chronically Exposed to Ozone

Alonso Martínez-canabal Physiology Department, School of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico DF
,
Mariana Angoa-Pérez Physiology Department, School of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico DF
,
Concepción Rugerio-Vargas Cellular and Tissular Biology Department, School of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico DF
,
Gabino Borgonio-Perez Physiology Department, School of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico DF
&
Selva Rivas-Arancibia Physiology Department, School of Medicine, National Autonomous University of Mexico, Mexico-City, Mexico DF
Pages 455-469 | Received 25 Jul 2007, Published online: 07 Jul 2009
 
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Abstract

The aim of this study was to determine GH-effects on Cyclooxygenase-2 (COX-2) expression on hippocampus alterations caused by ozone exposure. Seventy male rats were divided into: (1) control; (2) exposed to ozone for 7, 15, and 30 days; (3) exposed to ozone and treated with GH, for 7, 15, and 30 days. Results showed that lipoperoxidation levels and number of COX-2-positive cells increased in all groups exposed to ozone compared to control. In the groups treated with GH, COX-2 immunoreactive cell number decreased with respect to the ozone group. Therefore, GH could provide protection against damage induced by oxidative stress.

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