Advanced search
Publication Cover
International Journal of Neuroscience Volume 118, 2008 - Issue 11
Submit an article Journal homepage
34
Views
8
CrossRef citations to date
0
Altmetric
Original

Serotoninergic Mechanisms of Immunomodulation Under Different Psychoemotional States: I. A role of 5-HT1a Receptor Subtype

Galina Idova Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
,
Svetlana Davydova Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
,
Elizaveta Alperina Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
,
Margarita Cheido Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
&
Lidia Devoino Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
Pages 1594-1608 | Received 14 Jun 2007, Published online: 07 Jul 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

The present study demonstrates the involvement of serotonin (5-HT) receptors of the 5-HT1A type in immunoinhibitory effect of 5-HTergic system of the brain. A selective agonist of 5-HT1A receptors 8-OH-DPAT (1 mg/kg) induces the immunosuppression, whereas 5-HT1A blockade with WAY-100635 (1 mg/kg) resulted in immunostimulation. It is also shown that immunomodulating effects of the drugs were dependent on psychoemotional status of animals acquired aggressive or submissive behavior under social conflict conditions. Activation of 5-HT1A receptors produced a decrease of the immunity in aggressive mice, whereas 5-HT1A receptor blockade caused immunostimulation in submissive animals.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,997.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.