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International Journal of Neuroscience Volume 119, 2009 - Issue 9
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Chronic Ethanol-Induced Glial Fibrillary Acidic Protein (GFAP) Immunoreactivity: An Immunocytochemical Observation in Various Regions of Adult Rat Brain

Hakki Dalçik Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
,
Melda Yardimoglu Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
,
Serdar Fi˙li˙z Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
,
Süheyla Gonca Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
,
Cannur Dalçik Department of Anatomy, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
&
Beki˙r Faruk Erden Department of Pharmacology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey
Pages 1303-1318 | Received 09 Dec 2006, Published online: 09 Sep 2009
 
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Abstract

In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains. ETOH were administered as increasing concentrations of 2.4%–7.2% (v/v) gradually for 21 days. Immunocytochemistry revealed that chronic-ETOH treatment increased synthesis of GFAP. The increase in the diameter and the number of GFAP (+) cells were statistically significant compared with the control group (p <. 05). An increase of GFAP immunoreactivity was evident in various white matter and gray matter structures. We concluded that functional astrocytic cells responded to chronic ETOH exposure by increasing the synthesis of GFAP.

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