Role of S-100β in stroke

ABSTRACT

The S-100β levels are associated with a variety of acute disorders and other chronic diseases, such as head injury, stroke, metastatic melanoma, cardiac surgery, bone fractures, burns and contusions. The serum S-100β levels seem to increase with the volume of tissue damage. Higher serum S-100β levels have been observed after brain damage or stroke. A number of studies have evidenced the clinical value of S-100β in the diagnosis and prognosis of stroke while the S-100β marker is elevated in the peripheral blood during the acute phase of stroke. However, the clinical usefulness of S-100β biomarker in the diagnosis and prognosis of stroke has a limitation due to its low discriminating ability in stroke diagnosis and prognosis.

KEYWORDS:

• S-100β
• stroke
• diagnosis
• prognosis

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from Chongqing General Hospital [grant number CGHK201701]; Natural Science Foundation of Hubei Province [grant number 2015CFB260]; Hubei Province Health and Family Planning Scientific Research Project [grant number WJ2015MB219]; Shiyan Natural Science Foundation [grant number 15K70].