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International Journal of Neuroscience Volume 129, 2019 - Issue 9
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Case Reports

Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder subsequent to rhabdomyolysis: a case report and literature review

Ke ShangDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaView further author information
,
Chuan QinDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaView further author information
,
Bi-Tao BuDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaView further author information
&
Dai-Shi TianDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCorrespondence[email protected] [email protected]
View further author information
Pages 930-932 | Received 01 Nov 2018, Accepted 26 Jan 2019, Published online: 01 Mar 2019
 
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Abstract

Rhabdomyolysis could be caused by various mechanisms including autoimmune reaction. Here, we reported a case of 76-year-old-woman diagnosed with aquaporin-4 (AQP4) IgG positive neuromyelitis optica spectrum disorder (NMOSD) following rhabdomyolysis. After a review of literature, we propose that physical injury of skeletal muscle cells may lead to the production of AQP4 IgG and this AQP4 IgG might further decrease in the stability of skeletal muscle cells creating a positive feedback loop. HyperCKemia might be an inducement of NMOSD.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (grant nos. 81571132, 81873743).

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