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Abstract
Stroke is one of the major diseases that endanger the physical health life of middle-aged and old people. It has the characteristics of high incidence, mortality and disability rate. Atherosclerosis is the main intervention target for stroke prevention and treatment. MiRNAs are highly expressed in the cerebral vasculature and play an important regulatory role in the pathogenesis of neuronal damage and ischemic stroke. This article reviews the mechanism of action between miRNAs and atherosclerosis, stroke, ischemia-reperfusion injury, collateral circulation and circRNA molecular networks, providing theoretical support for miRNA in gene diagnosis and drug therapy of atherosclerotic stroke.
Compliance with ethical standards
This is a review on miRNA and atherosclerotic stroke, no biological specimens used, no ethics involved. On behalf of all authors, the corresponding author states that there is no conflict of interest. The work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part.
Disclosure statement
No potential conflict of interest was reported by the author(s).