Assessment of TREM2 rs75932628 variant’s association with Parkinson’s disease in a Greek population and Meta-analysis of current data

Abstract

Background

Α number of genetic variants are considered to confer susceptibility to Parkinson’s disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting.

Objective

Detection of a possible contribution of rs75392628 variant of TREM2 gene to PD risk.

Methods

A total of 358 PD patients and 358 healthy controls genotyped for rs75392628. In addition, a meta-analysis was performed by merging our results with those from previous studies.

Results

The rare variant of rs75932628 (47H) of TREM2 gene was not detected on cohort. Meta-analysis of a total of 9271 PD cases and 9777 controls across 14 independent PD data sets from 9 studies, including the present study, did not show any statistically significant effect of rs75392628 on PD risk (OR_FE:1.54 95% CI:0.87-2.73. OR_RE: 1.54, 95%CI: 0.71-3.32).

Conclusions

Rs75392628 TREM2 variant is rather unlikely to be a major genetic risk contributor of PD.

Keywords:

• PD
• TREM2
• rs75392628
• R47H
• genetic variant
• neurodegeneration
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.