Cardiovascular risk assessment after one-year acute ischemic stroke based on uric acid levels and renal dysfunction. A clinical study

Abstract

Background

The role of serum uric acid (SUA) after stroke is controversial and can be influenced by renal disease.

Aim

to analyse the role of SUA in the acute phase of stroke based on the presence/absence of kidney disease and cardiovascular outcome.

Methods

Retrospective cohort of a stroke registry followed-up for one year. The sample was divided according to the presence of renal disease defined by haematocrit, urea and gender (HUGE) formula, along with a SUA cut-off point obtained by receiver operating characteristic curves based on SUA levels and on the primary end-point occurrence.

Results

500 patients (268, 53.6% males) were analysed. Renal disease was present in 14.8% patients. The SUA cut-off for patients with renal disease was 404.46 μmol/L and 344.98 μmol/L for the remainder. Patients with higher SUA levels had decreased neurological disabilities (p = 0.04) and higher comorbidity (p = 0.00). Over a period of 42.3 (19) weeks, a primary end-point occurred in 17.4% patients. In the adjusted Cox model, SUA was associated with the primary end-point (HR 1.45, 95%CI 1.17-1.81, p = 0.01). Separated by the presence/absence of renal disease, SUA levels were associated with the primary endpoint for patients with renal disease (HR 1.29, 95%CI 1.06-1.58, p = 0.01) and for all other patients (HR 1.42, 95%CI 1.2-1.7, p = 0.00).

Conclusions

We observed a relationship between SUA levels and a negative cardiovascular outcome after ischaemic stroke both in patients with and without renal disease, with the worst outcomes occurring in patients with renal insufficiency.

Keywords:

• Uric acid
• ischemic stroke
• chronic kidney disease

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

• Conception or design of the work: José Carlos Arévalo-Lorido; N.Roberto Robles.

• Acquisition of the data: José Carlos Arévalo-Lorido; Juana Carretero-Gómez.

• Analysis and interpretation of data for the work: José Carlos Arévalo-Lorido.

• Drafting the work or revising it critically for important intellectual content: all the authors.

• Final approval of the version to be published: all the authors.