Rab11-mediated recycling endosome role in nervous system development and neurodegenerative diseases

Abstract

Study:

Membrane trafficking process is significant for the complex and precise regulatory of the nervous system. Rab11, as a small GTPase of the Rab superfamily, controls endocytic vesicular trafficking to the cell surface after sorting in recycling endosome (RE), coordinating with its receptors to maintain neurological function.

Materials and methods

This article reviewed the literature of Rab11 in nervous system.

Results

Rab11-positive vesicles targeted transport growth-related molecules, such as integrins, protrudin, tropomyosin receptor kinase (Trk) A/B receptor and AMPA receptor (AMPAR) to membrane surface to promote the regeneration capacity of axon and dendrites and maintain synaptic plasticity. In addition, many studies have shown that the expression of Rab11 is decreased in multiple neurodegenerative diseases, which is highly correlated with the process of production, transport and clearance of disease-related pathological proteins. And overexpression or increased activity of Rab11 can greatly improve the defect of membrane trafficking and slow down the disease process.

Conclusion

With increasing research efforts on Rab11-dependent membrane trafficking mechanisms, a potential target for nerve regeneration and neurodegenerative diseases will be provided.

Keywords:

• Rab11
• Rab proteins
• recycling endosome
• nervous system
• neurodegenerative diseases
• vesicle trafficking

Acknowledgments

The authors would like to thank the Lanzhou University for providing the research grant.

Disclosure statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (31870335); the Health Industry Planning Project of Gansu Provincial Health and Family Planning Commission (GSWSKY 2016-17); the Science and Technology Major Special Collaboration Project of Gansu Provincial Key Laboratory of Gene Function (BA2016036); the “Cuiying Technology Innovation” Planning Project of Lanzhou University Second Hospital (CY2017-MS19); Cuiying Graduate Supervisor Applicant Training Program Of Lanzhou University Second Hospital (201802); and the Key Laboratory of Biotherapy and Regenerative Medicine, Gansu Province (zdsyskfkt- 201703).