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International Journal of Neuroscience Volume 133, 2023 - Issue 9
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Original Articles

Opportunities and challenges: mesenchymal stem cells in the treatment of multiple sclerosis

Yingyu ZhangDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0003-4566-7151View further author information
ORCID Icon,
Jiebing GuDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0003-0844-5859View further author information
ORCID Icon,
Xiaoshuang WangDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-8655-0796View further author information
ORCID Icon,
Linfang LiDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-6350-6442View further author information
ORCID Icon,
Lingling FuDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-7410-3550View further author information
ORCID Icon,
Di WangDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0001-9293-9039View further author information
ORCID Icon,
Xiuting WangDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-6965-4729View further author information
ORCID Icon &
Xuemei HanDepartment of Neurology, China-Japan Union hospital of Jilin University, Changchun city, Jilin, P.R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4423-2079View further author information
ORCID Icon show all
Pages 1031-1044 | Received 17 Sep 2021, Accepted 09 Feb 2022, Published online: 17 May 2022
 
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Abstract

Multiple sclerosis (MS) was once considered an untreatable disease. Through years of research, many drugs have been discovered and are widely used for the treatment of MS. However, the current treatment can only alleviate the clinical symptoms of MS and has serious side effects. Mesenchymal stem cells (MSCs) provide neuroprotection by migrating to injured tissues, suppressing inflammation, and fostering neuronal repair. Therefore, MSCs therapy holds great promise for MS treatment. This review aimed to assess the feasibility and safety of use of MSCs in MS treatment as well as its development prospect in clinical treatment by analysing the existing clinical studies.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Project of Health research talents Project of Jilin Province(2019sc2018; 20201231SY006) and the Project of Jilin Province Development and Reform Commission(2021C043-6) in China.

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