Preparation and Properties of Poly(D,L-lactide-co-glycolide-co-ε-caprolactone)/1,4-Butanediamine Modified Poly(lactide-co-glycolide) Blend Porous Microspheres

Abstract

Composite porous microspheres based on blends of poly(D,L-lactide-co-glycolide-co-ε-caprolactone) (PLGCL) and 1,4-butanediamine modified poly(D,L-lactide-co-glycolide) (BMPLGA) were prepared by using a combined solvent evaporation and particle leaching technique. The morphologies and porous structure of the PLGCL/BMPLGA microspheres were observed by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and cytocompatibility were studied. The resultant microspheres showed a porous surface and a three-dimensional network structure with interconnecting pores. The changes of morphologies, pH value and mass loss during in-vitro degradation in phosphate buffered solution (PBS) at 37°C indicated that the degradation rate of the BMPLGA was faster than that of the PLGCL in the PLGCL/BMPLGA blends. We suggest the PLGCL/BMPLGA porous microspheres were non-cytotoxic and showed excellent cytocompatibility. We suggest the PLGCL/BMPLGA porous polymeric microspheres have great potential for application for drugs delivery and tissue regeneration.

Keywords:

• 1,4-butanediamine modified poly(lactide-co-glycolide)
• cytocompatibility
• in-vitro degradation
• poly(lactide-co-glycolide-co-ε-caprolactone)
• porous microspheres

Additional information

Funding

This work was financially supported by the National Natural Science Fund of China (No. 51773057) and National Experimental Teaching Demonstration Center of Chemical Engineering and Materials (# 2016[7]).