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Journal of Macromolecular Science, Part B
Physics
Volume 61, 2022 - Issue 10-11
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Articles

In-Vitro Degradation and Biological Properties of Poly(Lactide-co-Glycolide-co-ε-Caprolactone)/Ethanediamine Modified Poly(Lactide-co-Glycolide) Blend Scaffolds

Zemei Fanga School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
,
Zhihua Zhoua School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China;b Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan, P. R. China;c Hunan Province College Key Laboratory of Molecular Design and Green Chemistry, Hunan University of Science and Technology, Xiangtan, P. R. ChinaCorrespondence[email protected]
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Wei Wud Daqing Petrochemical Research Institute of CNPC, Daqing, P. R. ChinaView further author information
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Wenjuan Liub Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
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Hailin Xiea School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
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Hongbo Hua School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
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Yan Gana School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaView further author information
&
Jianjun Fanga School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. ChinaCorrespondence[email protected]
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Pages 1270-1281 | Received 12 Oct 2022, Accepted 10 Dec 2022, Published online: 19 Jan 2023
 
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Abstract

A degradable blend scaffold composed of poly(D,L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) and ethanediamine modified poly(lactide-co-glycolide) (EMPLGA) was prepared by using a thermally induced phase separation technique. The morphologies of the PLLGC/EMPLGA blend scaffolds were characterized by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and biocompatibility of the individual components and the blend were investigated by using rat L929 cells. The blend scaffolds showed a porous and well interconnected pore structure. The degradation rate sequence of the three scaffolds, the individual components and the blend, was EMPLGA > PLLGC/EMPLGA > PLLGC. The PLLGC/EMPLGA blend scaffold was non-cytotoxic and showed high cell proliferation.

Additional information

Funding

This work was financially supported by Scientific Research Fund of the Hunan Provincial Education Department (No. 21A0323).

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