Motor Performance Improved by Exercises in Cerebral Ischemic Rats

ABSTRACT

Physical exercise may induce neuroprotective effects against brain damage after stroke. The authors aimed to investigate the effects of various exercises on motor function, striatal angiogenesis, and infarct volume in cerebral ischemic rats. Adult male Sprague Dawley rats were subjected to middle cerebral artery occlusion and randomly assigned to 1 of the 4 groups: Rota-rod training, lower speed treadmill training, higher speed treadmill training, or no exercise control. Motor function, striatal angiogenesis, and infarct volume were evaluated before or after motor training. After training, motor function and striatal angiogenesis changed significantly in Rota-rod and higher speed treadmill training groups as compared with the control group. Improvement in motor function significantly correlated with striatal angiogenesis after motor training. Infarct volumes were significantly decreased in lower and higher speed treadmill training groups. The results indicated that both motor training procedures can be used as effective training programs in stroke rehabilitation.

Keywords:

• angiogenesis
• middle cerebral artery occlusion
• motor function
• motor training
• striatum

ACKNOWLEDGMENTS

This work was supported by the National Science Council (Grant No. NSC 95-2314-B-010-004 & NSC 96-2314-B-010-001) of Republic of China.