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Original Articles

Light scattering of liposomal structure of 1,2-distearoyl-sn-glycero-3-phosphocholine and cholesterol with NaCl

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Pages 436-441 | Received 02 Aug 2013, Accepted 15 Nov 2013, Published online: 30 Apr 2014
 

Abstract

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol are used to prepare liposome. Dynamic light scattering was used to study the dynamics of different concentration of the DSPC on liposomal structure. The results show that with increase of DSPC concentration the diffusion coefficient decreases. The small angle X-Ray scattering (SAXS) experiments show that an increase of the DSPC of 0.5–5% changes the size of liposomal structure from 35 to 112 nm, this is analysed in leaves of hard sphere core shell model. Moreover, the addition of NaCl at 0.001 molar can decrease the size of liposomal structure.

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