Determination of Abraham model solute descriptors for 2-methyl-3-nitrobenzoic acid from measured solubility data in alcohol, alkyl ether, alkyl acetate and 2-alkoxyalcohol mono-solvents

ABSTRACT

Spectroscopic methods are employed to measure the solubility of 2-methyl-3-nitrobenzoic acid dissolved in 10 alcohol, 3 alkyl ether, 5 alkyl acetate and 3 alkoxyalcohol solvents at 298.2 K. 2-Methyl-3-nitrobenzoic acid is believed to exist in monomeric form in each of the organic solvents studied. The measured solubilities are used to calculate the Abraham model solute descriptors for the monomeric form of 2-methyl-3-nitrobenzoic acid, which will enable one to predict the solubility of 2-methyl-3-nitrobenzoic acid in additional organic solvents. The derived solute descriptors back-calculated the observed solubility data to within 0.06 log units.

KEYWORDS:

• 2-Methyl-3-nitrobenzoic acid solubility
• Abraham model solute descriptors
• alcohol solvents
• alkoxyethanol solvents
• alkyl acetate solvents
• alkyl ether solvents

Acknowledgements

Maribel Barrera thanks the University of North Texas and the U.S. Department of Education for support provided under the Ronald E. McNair Postbaccalaureate Achievement Program.

Disclosure statement

No potential conflict of interest was reported by the authors.