Determination of Abraham model solute descriptors for monomeric 3,4,5-trimethoxybenzoic acid from experimental solubility data in organic solvents measured at 298.2 K

ABSTRACT

Spectroscopic methods are employed to determine the experimental solubility of 3,4,5-trimethoxybenzoic acid dissolved in propylene carbonate, in 19 alcohol, in 4 alkyl ether, in 5 alkyl alkanoate and in 4 alkoxyalcohol solvents at 298.2 K. 3,4,5-Trimethoxybenzoic acid is believed to exist predominantly in monomeric form in each of the 34 organic solvents studied. The measured solubilities in 29 of the organic solvents are used to calculate the Abraham model solute descriptors for the monomeric form of 3,4,5-trimethoxybenzoic acid. Solubilities in the remaining five solvents could not be used in the solute descriptor computations because Abraham model equation coefficients are not available for these solvents. The derived solute descriptors back-calculated the observed solubility data to within 0.10 log units.

KEYWORDS:

• 3,4,5–Trimethoxybenzoic acid solubilities
• solute descriptors
• Abraham solvation parameter model
• organic solvents

Acknowledgements

Olivia Zha, Anisha Wadawadigi and Ellen Qian thank the University of North Texas’s Texas Academy of Math and Science (TAMS) programme for a summer research award. Sarah Dunn, Janna Herron, Ketsia Kankolongo and Shy’an Ryan thank the US Department of Education for support provided to them under the Upward Bound Math and Science Programme.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Olivia Zha, Anisha Wadawadigi and Ellen Qian thank the University of North Texas’s Texas Academy of Math and Science (TAMS) programme for a summer research award. Sarah Dunn, Janna Herron, Ketsia Kankolongo and Shy’an Ryan thank the US Department of Education for support provided to them under the Upward Bound Math and Science Programme.