Solubility of celecoxib in carbitol + water mixtures at various temperatures: experimental data and mathematical modelling

ABSTRACT

A brief review on various solubilisation techniques of coxibs is provided and the solubility of celecoxib (CXB) in binary solvent mixtures of {carbitol (1) + water (2)} is reported at temperatures ranging from 298.2 to 313.2 K. Three cosolvency models, i.e. Yalkowsky model, Jouyban–Acree model and the Jouyban–Acree–van’t Hoff model, have been used for correlating the reported data, and the mean relative deviations are employed to evaluate the accuracy of the fitness. Solubilities are also predicted by the generally trained version of the Jouyban–Acree model and its combined model with Abraham solute parameters previously proposed for {carbitol (1) + water (2)} binary mixtures. Furthermore, the apparent thermodynamic properties of dissolution process of CXB in all -investigated solvents were calculated according to van’t Hoff and Gibbs equations.

KEYWORDS:

• Solubility
• celecoxib
• carbitol
• Jouyban–Acree model
• van’t Hoff equation

Acknowledgments

Research reported in this publication was supported by Student Research Committee under grant number [57430], Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Student Research Committee under grant number [57430].