Solubility of acetaminophen in 1-propanol + water mixtures at T = 293.2–313.2 K

ABSTRACT

The mole fraction solubilities of acetaminophen (ACP) were measured in the binary solvent mixtures of {1-propanol + water} at T = 293.2–313.2 K. The Jouyban–Acree, Jouyban–Acree–van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R-K) and modified Wilson models as well as a non-linear model presented by Machatha et al. were used to correlate the measured equilibrium solubilities. Furthermore, the experimental data were predicted with five predictive models, i.e. Yalkowsky, extended Yalkowsky as well as trained versions of Yalkowsky, Jouyban–Acree and Jouyban–Acree–Hansen models. Moreover, the apparent standard molar Gibbs energy, enthalpy, and entropy of dissolution and mixing ($\mathrm{\Delta }{G}_{soln}^{\circ }$, $\mathrm{\Delta }{H}_{soln}^{\circ }$, $\mathrm{\Delta }{S}_{soln}^{\circ }$, $\mathrm{\Delta }{G}_{mix}^{\circ }$, $\mathrm{\Delta }{H}_{mix}^{\circ }$, $\mathrm{\Delta }{S}_{mix}^{\circ }$) of ACP in {1-propanol (1) + water (2)} mixtures were calculated at mean harmonic temperature T_hm = 303 K based on van’t Hoff and Gibbs free energy equations. Additionally, preferential solvation parameters of ACP in the mixtures were also analysed based on the inverse Kirkwood–Buff integrals.

KEYWORDS:

• Acetaminophen
• solubility
• 1-propanol
• Jouyban–Acree model
• modified Wilson model
• thermodynamics of dissolution
• preferential solvation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Elite Researcher Grant Committee, the National Institutes for Medical Research Development (NIMAD), Tehran, Iran [grant number 943610].