Preferential solvation of 4-(4-ethoxyphenyl)-5-(3,4,5-trimethoxybenzoyl)-3,4-dihydropyrimidin-2(1H)-one in {PEG 400 (1) + water (2)} mixtures

ABSTRACT

The reported equilibrium mole fraction solubility of 4-(4-ethoxyphenyl)-5-(3,4,5-trimethoxybenzoyl)-3,4-dihydropyrimidin-2(1H)-one (DHP-5) in some {polyethylene glycol (PEG 400 (1) + water (2)} mixtures at 298.2 K has been used to evaluate the preferential solvation of this compound by the mixture components. First, molar volume and Hildebrand solubility parameter of DHP-5 were calculated as 277.7 cm³ mol^–1 and 25.11 MPa^1/2, respectively, by means of Fedors’ method. In this way, by using the inverse Kirkwood–Buff integrals method, it is observed that this compound is preferentially solvated by PEG molecules in all the mixtures. Thus, maximum preferential solvation parameter by PEG was observed in the mixture x₁ = 0.15 being 1.55 × 10^–2.

KEYWORDS:

• 4-(4-Ethoxyphenyl)-5-(3-trimethoxybenzoyl)-3-dihydropyrimidin-2(1H)-one
• (PEG 400 + water) mixtures
• solubility
• preferential solvation

Disclosure Statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The research reported in this publication was supported by a grant [62733] from Research Affairs, Tabriz University of Medical Sciences, Tabriz, Iran.