Solubility of mesalazine in {acetonitrile + water} mixtures at various temperatures

ABSTRACT

The solubility of mesalazine in {acetonitrile + water} mixtures was reported at T = (293.2–313.2) K and correlated with some cosolvency models namely van’t Hoff, Apelblat, Jouyban-Acree, Jouyban-Acree-van’t Hoff, combined nearly ideal binary solvent/Redlich-Kister, modified Wilson, NRTL and UNIQUAC models. The Yalkowsky and extended Yalkowsky models were employed to predict the solubility data. The apparent thermodynamic quantities of dissolution and mixing for mesalazine in aqueous acetonitrile solutions were computed. Finally, preferential solvation analysis demonstrates that mesalazine is preferentially solvated by water in almost all the mixtures, except in the region 0.19 < x₁ < 0.29.

KEYWORDS:

• Solubility
• mesalazine
• acetonitrile
• cosolvency models
• thermodynamic properties
• preferential solvation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The research reported in this publication was supported by a grant [62733] of Research Affairs, Tabriz University of Medical Sciences, Tabriz, Iran.