ABSTRACT
Three co-solvent mixtures {methanol (1) + ethyl acetate (2), ethanol (1) + ethyl acetate (2), and isopropanol (1) + ethyl acetate} were used to calculate the preferred solvation parameters () of musk ketone (MK) (2). In all co-solvent mixes,
values vary non-linearly with the percentage of co-solvent (1). According to the study,
values are negative in mixes rich in alcohol but positive in those high in ethyl acetate. The mixtures {methanol (1) + ethyl acetate (2)} and {ethanol (1) + ethyl acetate (2)} show the most favoured solvation of MK by ethyl acetate at 298.15 K and 293.15 K, respectively. When {isopropanol (1) + ethyl acetate (2)} is combined; it is maximum at 298.15 K. Since the
values are positive, MK preferentially solvates with ethyl acetate. The most significant values for x1 = 0.18–0.40 are obtained towards the non-polar regions of MK for the three co-solvent mixes.
Acknowledgments
The authors extend their appreciation to the Deputyship of Scientific Research at Northern Border University, Arar, KSA for funding this research work through the project number “NBU-FFR-2023-0085.ˮ
Disclosure statement
No potential conflict of interest was reported by the authors.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/00319104.2023.2275319