Musk ketone solubility in binary systems ethyl acetate with methanol, ethanol, and isopropanol: preferential solvation according to the inverse Kirkwood–Buff integrals method

ABSTRACT

Three co-solvent mixtures {methanol (1) + ethyl acetate (2), ethanol (1) + ethyl acetate (2), and isopropanol (1) + ethyl acetate} were used to calculate the preferred solvation parameters ($\delta x_{1,3}$) of musk ketone (MK) (2). In all co-solvent mixes, $\delta x_{1,3}$ values vary non-linearly with the percentage of co-solvent (1). According to the study, $\delta x_{1,3}$values are negative in mixes rich in alcohol but positive in those high in ethyl acetate. The mixtures {methanol (1) + ethyl acetate (2)} and {ethanol (1) + ethyl acetate (2)} show the most favoured solvation of MK by ethyl acetate at 298.15 K and 293.15 K, respectively. When {isopropanol (1) + ethyl acetate (2)} is combined; it is maximum at 298.15 K. Since the $\delta x_{1,3}$ values are positive, MK preferentially solvates with ethyl acetate. The most significant values for x₁ = 0.18–0.40 are obtained towards the non-polar regions of MK for the three co-solvent mixes.

KEYWORDS:

• Musk ketone
• co-solvent + ethyl acetate mixtures
• inverse Kirkwood–Buff integrals (IKBI)
• preferential salvation

Acknowledgments

The authors extend their appreciation to the Deputyship of Scientific Research at Northern Border University, Arar, KSA for funding this research work through the project number “NBU-FFR-2023-0085.ˮ

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/00319104.2023.2275319

Additional information

Funding

The work was supported by the Deputyship of Scientific Research at Northern Border University [NBU-FFR-2023-0085].