Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols

ABSTRACT

Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols.

KEYWORDS:

• Glibenclamide
• solubility
• binary mixtures

Acknowledgments

The Student Research Committee approved and supported the research protocol under grant number 71928, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data Availability statement

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

The work was supported by Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran [71928].