Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers

ABSTRACT

Objective: Ibuprofen is a commonly used non-steroidal anti-inflammatory drug administered to treat injuries, joint pain, and recurrent muscular skeletal pain. The aim of this study was to determine the cutaneous irritancy of a medicated ibuprofen plaster compared with a placebo plaster in healthy volunteers.

Methods: Healthy volunteers (N = 31) were treated at the same time with one ibuprofen and one placebo plaster. The ibuprofen and placebo plaster were applied in a randomized fashion to sites on the left or right side of subjects’ lower backs. At each scheduled visit, the plasters and applications sites were assessed for degree of adhesion and skin irritancy, respectively. The plasters were applied on study Days 1, 2, 3, 5, 8, 10, 12, 15, 17, and 19, with final plaster removal on Day 22.

Results: The ibuprofen medicated plaster compared with placebo had a lower percentage of Grade 1 (23.3% vs. 46.7%, respectively), Grade 2 (10% vs. 20%), and ≥Grade 3 (3% vs. 16.1%) irritancy scores after 21 days of application. The mean irritation score across the study was 0.40 for the ibuprofen medicated plaster and 1.18 for the placebo plaster. The irritation score on Day 22 of the study was 0.53 for the ibuprofen medicated plaster and 1.50 for placebo. The placebo plaster was associated with a higher number of stopped applications due to Grade 3 or above skin reactions compared with the ibuprofen medicated plaster (5 vs. 1, respectively).

Conclusion: The ibuprofen medicated plaster was well tolerated and was associated with lower irritancy than the placebo plaster.

KEYWORDS:

• Ibuprofen
• plaster
• patch
• NSAIDs
• cutaneous reaction
• irritancy

Acknowledgments

The authors would like to thank Dr. Sue Aspley who contributed to the study design and oversaw the study conduct and Gary Smith provided statistical inputs and analysis.

Declaration of interest

M Maganji and A Bhatt are employees of Reckitt Benckiser. MP Connolly is a consultant for Reckitt Benckiser. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Additional information

Funding

The study was supported by Reckitt Benckiser, Slough, United Kingdom