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Clinical Focus: Diabetes - Original Research

Statin-induced new onset of diabetes in dyslipidemic patients: a retrospective study

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Pages 383-387 | Received 16 Apr 2019, Accepted 11 Jul 2019, Published online: 05 Aug 2019
 

ABSTRACT

Background: Previously conducted studies with statins shows an increased risk of developing new onset of diabetes. This study helps in analyzing the risk of statins to cause new onset of diabetes.

Objective: To assess the prevalence, causality, severity, preventability and risk factors of statin-induced new onset of diabetes in dyslipidemic patients.

Methods: The study was conducted in a tertiary care hospital. A 6-month retrospective study was carried out in the cardiology department and analyzed between year 2013-2017medical records of dyslipidemic patients treated with statins of age >18 years. Patients with congenital diabetes, previous history of diabetes, patients using antipsychotics and steroids, and patients with incomplete data were excluded. Patients were reported as diabetic according to the American Diabetes Association’s classification. Patients who developed statin-induced new onset of diabetes were assessed by the WHO probability scale, Naranjo’s causality assessment scale, Hartwig’s severity assessment scale, and Modified Schumock and Thornton preventability scale.

Results: Out of 270 dyslipidemic patients, 19 patients developed statin-induced new onset of diabetes and 69 were classified as pre-diabetic. The major risk factors were: dose, gender, age, geriatric patients, and duration of the therapy. Patients who developed statin-induced new onset of diabetes were managed by dose reduction and treatment with anti-diabetic medications.

Conclusion The prevalence of statin-induced new onset of diabetes is 7.03%. The main risk factors identified in the study were in older patients (≥60 years), rosuvastatin therapy, high dose and longer duration of statin therapy.

Acknowledgments

We would like to thank NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Deralakatte, Karnataka, Mangaluru for providing the research facilities for conducting this study.

Declarations of interest

The authors and peer reviewers on this manuscript do not have any conflicts of interest to disclose.

Additional information

Funding

This paper was not funded.

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