Primary hyperparathyroidism associated with non-Hodgkin lymphoma: a case report and literature review

ABSTRACT

Primary hyperparathyroidism is the third most common endocrine disease, while primary hyperparathyroidism associated with non-Hodgkin lymphoma(NHL) is extremely rare. We report a case of primary hyperparathyroidism associated with NHL. The first symptom of this patient was hypercalcemia. Hypercalcemia is the primary first clinical manifestation of primary hyperparathyroidism, while NHL may also be diagnosed by hypercalcemia. Clinically, patients with hypercalcemia as the first symptom should be alert to the coexistence of their two diseases. As primary hyperparathyroidism and NHL occur simultaneously, the relationship between the two diseases requires further study. A review of the literature regarding primary hyperparathyroidism associated with NHL was performed, focusing on clinical presentation, diagnosis, treatment, prognosis, and the connection.

KEYWORDS:

• Primary hyperparathyroidism
• parathyroid adenoma
• non-Hodgkin lymphoma
• diffuse large B-cell lymphoma
• hypercalcemia
• connection

Statement of ethics

Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Peer reviewers on this manuscript have no relevant financial relationships or otherwise to disclose.

Additional information

Funding

The manuscript was supported by grants from The National Natural Science Funds of China (No. 81760168).