The clinical course and short-term health outcomes of multisystem inflammatory syndrome in children in the single pediatric rheumatology center

ABSTRACT

Objectives

Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe condition resulting in excessive response of the immune system after SARS-CoV-2 infection. We report a single-center cohort of children with MIS-C, describing the spectrum of presentation, therapies, clinical course, and short-term outcomes.

Methods

This is a prospective observational study from to a tertiary pediatric rheumatology center including patients (aged 1 month to 21 years) diagnosed with MIS-C between April 2020-April 2021. Demographic, clinical, laboratory results and follow-up data were collected through the electronic patient record system and analyzed.

Results

A total of 67 patients with MIS-C were included in the study. Fever was detected in all patients; gastrointestinal system symptoms were found in 67.2% of the patients, rash in 38.8%, conjunctivitis in 31.3%, hypotension in 26.9% myocarditis, and/or pericarditis in 22.4%, respectively. Respiratory symptoms were only in five patients (7.5%). Kawasaki Disease like presentation was found 37.3% of the patients. The mean duration of hospitalization was 11.8 7.07 days. Fifty-seven patients (85%) received intravenous immunoglobulin (IVIG), 45 (67%) received corticosteroids, 17 (25.3%) received anakinra, and one (1.5%) received tocilizumab. Seven of the patients (10.4%) underwent therapeutic plasma exchange (TPE). In 21 (31.3%) patients, a pediatric intensive care unit (PICU) was required in a median of 2 days. The first finding to improve was fever, while the first parameter to decrease was ferritin (median 6.5 days (IQR, 4–11.2 days)). Sixty-five patients were discharged home with a median duration of hospital stay of 10 days (IQR, 7–15 days).

Conclusion

Patients with MIS-C may have severe cardiac findings and intensive care requirements in admission and hospital follow-up. The vast majority of these findings improve with effective treatment without any sequelae until discharge and in a short time in follow-up. Although the pathogenesis and treatment plan of the disease are partially elucidated, follow-up studies are needed in terms of long-term prognosis and relapse probabilities.

KEYWORDS:

• Multisystem inflammatory syndrome in children
• pediatric
• COVID-19
• outcome 4

Acknowledgments

We are grateful to all participating children and their families.

Author contributions

Conception and design; BS, SÇ, VA, KU, TÇ, ÖPA, CHA, GA, ES, MK, TÖ, SE and FD, Analysis and interpretation of the data; BS and FD, Drafting of the paper or revising it critically for intellectual content; BS and FD, The final approval of the version to be published; BS, SÇ, VA, KU, TÇ, ÖPA, CHA, GA, ES, MK, TÖ, SE and FD, and all authors agree to be accountable for all aspects of the work.R