Comparison of pediatric patients with idiopathic uveitis, and uveitis due to juvenile idiopathic arthritis and Behçet’s disease

ABSTRACT

Objectives

The aim of this study is to compare the demographic, clinical features, treatment results and outcomes in pediatric patients with idiopathic uveitis and uveitis due to juvenile idiopathic arthritis (JIA) and Behçet’s disease (BD).

Methods

97 pediatric uveitis patients were divided into three groups according to the etiology of uveitis: Group 1 comprised idiopathic uveitis patients, Group 2 uveitis patients who had JIA, and Group 3 uveitis patients with BD.

Results

Symptomatic presentation and intermediate uveitis were more common in Group 1 (p < 0.005). Asymptomatic presentation and anterior uveitis in Group 2 (p < 0.005), whereas symptomatic presentation and posterior uveitis in Group 3 (p < 0.005). Erythrocyte sedimentation rate (ESR) was higher in patients with BD or JIA uveitis than those with idiopathic uveitis (p < 0.005). Biologic therapy was more commonly used in JIA group compared to other groups (p < 0.005). Patients who had a complication related with uveitis were more common in females, asymptomatic disease course, and needed use of biologic treatment than in those without any complication (p < 0.005).

Conclusion

Uveitis accompanying rheumatologic diseases may have asymptomatic and insidious course but have higher ESR as an important notice.

KEYWORDS:

• Juvenile idiopathic arthritis
• pediatric behçet’s disease
• pediatric rheumatology
• treatment
• uveitis

Acknowledgments

The authors are grateful to all participating children and their families.

Author contributions

DGY, MH, and SAB contributed to the study design, case recruitment, acquisition and interpretation of data, statistical analysis, writing the manuscript and multiple revisions, final approval of the manuscript. DGY, MH, and SAB contributed to data acquisition, manuscript revision, and final approval of the manuscript. DGY, MH, and SAB contributed to interpretation of data, statistical analysis, multiple revisions of the manuscript, and final approval of the manuscript. All authors read and approved the final manuscript.

Declaration of interest

No potential conflict of interest was reported by the authors.

Disclosure of any financial/other conflicts of interest

The authors declare there are no conflicts of interest-financial or otherwise-related to the material presented herein. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Data sharing

The data that support the findings of this study are available from the corresponding author, DGY, upon reasonable request.

Additional information

Funding

The authors have no funding to report.