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Transactions of the Royal Society of South Africa Volume 73, 2018 - Issue 2
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Circulating endothelial and endothelial progenitor cells in microvascular repairs in pancreatic hyperglycaemic-induced damage: a review

Danie J. Le RouxIslet and MSK Research Group, Anatomy and Histology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, South Africa
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Venant Tchokonte-NanaIslet and MSK Research Group, Anatomy and Histology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, South AfricaCorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0003-2240-3735
ORCID Icon
Pages 186-192 | Published online: 19 Jun 2018
 
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Abstract

The body vasculature contains an inner lining of endothelium, which consists of highly metabolic active endothelial cells (ECs). In microvascular damage resulting from the detrimental physiological effects of hyperglycaemia, ECs are unable to change their glucose transport rate. This results in the mobilisation and recruitment of endothelial progenitor cells (EPCs) to the site of injury for neovascularisation and vascular repair. This review assessed the implications of circulating endothelial and endothelial progenitor cells (CEPCs) on pancreatic microvascular repair and highlighted the impact of EPCs in neovascularisation. This insight information may open up new avenues of research on novel approaches to maintaining and regenerating microvasculature in diabetes mellitus.

ORCID

Venant Tchokonte-Nana http://orcid.org/0000-0003-2240-3735

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