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Original Article

Supportive evidence by field testing and laboratory experiment for a new hypothesis of the ecology and pathogenicity of canine blastomycosis

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Pages 22-32 | Published online: 09 Jul 2009
 

Abstract

This paper offers evidence showing that the pathogenicity of Blastomyces dermatitidis involves the following: 1. Infection with B. dermatitidis in dogs is very severe. Among 33 infected dogs almost 20% died, all but one with eye lesions. In addition, 70% developed skin lesions in the first 66 weeks of observation. 2. The skin test appears to be a useful tool in defining dogs probably infected with B. dermatitidis. 3. Serologic tests do not appear useful as indicators of infection because cross reactions with histoplasmin are frequent. 4. Field skin testing of dogs with blastomycin and histoplasmin indicates that it is extremely useful in detecting infected dog packs and premises. Almost half of more than 100 dogs in the area of the only known blastomycosis epidemic in North Carolina showed specific blastomycin tests as contrasted with an 11–18% rate in mongrel dogs in Kentucky. Skin testing of 20 fox hound packs in Kentucky has revealed 8 premises where 35% or more of the dogs show positive specific blastomycin skin tests.

Resumen

Este estudio ofrece evidencia que demuestra la patogenicidad de Blastomyces dermatitidis y cubre los siguientes conceptos: 1. La infección con B. dermatitidis en perros es muy severa. De 33 perros infectados cerca de un 20% murieron, todos excepto uno, con lesiones en los ojos. Adexnás 70% desarollaron lesiones cutáneas en las primeras 66 semanas de observación. 2. La prueba intradérmica parece ser un arma muy efectiva en la identificación de perros probablemente infectados con B. dermatitidis. 3. Las pruebas serológicas no parecen ser útiles como indicadores de infección debido a que reacciones cruzadas con histoplasmina son frecuentes. 4. Pruebas intradérmicas efectuadas en perros con blastomicina e histoplasmina indican que la prueba intradérmica es extremadamente útil para señalar grupos de perros y predios posiblemente infectados. Casi la mitad de más de 100 perros en el área de la única epidemia conocida de blastomicosis en Grifton, Carolina del Norte, demostraron ser positivos a pruebas de blastomicina comparado conun 11–18% en perros mestizos en Kentucky. Pruebas intradérmicas en 20 grupos de perros zorreros reveló 8 predios donde el 35% o más manifestaron resultados positivos.

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